Miedzo yekiriniki yezvirwere zvemwoyo inosimbisa Attruby muATTR-CM ukuwo GLP-1s neCHAMPION-AF zvichiumba remangwana rehutano hwemwoyo

Nyanzvi dzezvirwere zvemwoyo dziri kupinda mune imwe nguva yekuchinja kukuru, nemiedzo mikuru yekiriniki ichichinja kurapa kwezvirwere zvemwoyo. Kubva mukutsvagurudza kunoratidza kuwedzera kwekubatsira kwezvirwere zvemwoyo zveGLP-1 receptor agonists kusvika kuhumbowo hutsva hunobatanidza atrial fibrillation neATTR-CM, zvidzidzo zvechangobva kuitwa zviri kuratidza kuti ramangwana rekutarisira varwere richatungamirwa kwete nechipikirwa chete, asi nehumbowo hwakasimba hwekiriniki. Kukundikana kweWainua mukuyedzwa kwePhase III muenzaniso wakajeka, kusimbisa nzira yekurapa yeATTR-CM iripo uye kusimbisa nyaya yekurapa kwakatangwa, senge BridgeBio's Attruby.

Wainua inosimbisa Attruby senzira inodiwa yekurapa ATTR-CM

Zvidzidzo zvishoma zvezvemoyo zvakakwezva vanhu vakawanda gore rino sekutongwa kweAstraZeneca kwePhase III Wainua mu transthyretin amyloid cardiomyopathy (ATTR-CM). Tarisiro dzaive dzakakura dzekuti kuwedzera Wainua mukurapa kwe transthyretin stabilizer kwaizowedzera kuvandudza mhedzisiro yevarwere vanorarama nechirwere ichi chinofambira mberi uye chinopedza hupenyu. Pane kudaro, bvunzo iyi yakakundikana kusvika pamugumo wayo wekutanga, isina kuratidza kudzikira kwakakosha mukufa kwemwoyo kana zviitiko zvemwoyo zvinogara zvichiitika apo Wainua yakawedzerwa kuchipatara chemazuva ese.

Chidzidzo ichi chakanyoresa varwere 1,432 mukati memavhiki zana nemakumi mana, asi vanopfuura hafu (57%) vakanga vatogamuchira transthyretin stabilizers pakunyoresa, uye vamwe 24% vakatanga imwe panguva yekuedzwa. Vaongorori vakati izvi zvakaita kuti zviome kuratidza chero rubatsiro rwakawedzerwa kubva kuWainua pamusoro pemishonga iripo, zvichizomutsa mibvunzo yekuti dhizaini yechidzidzo ichi yaivhara here mukana wemushonga pane kuubvisa zvachose.

Pane kugadzirisa mamiriro ekurapa, mhedzisiro yacho inosimbisa kusimba kwemaitiro ekurapa aripo. Pasina kuratidzwa kwekubatsira kubva mukuwedzera Wainua pamusoro pekurapa kunodzora, zvakawanikwa izvi zvinosimbisa nyaya yeBridgeBio's. Attruby senzira inodiwa yekurapa ATTR-CM.

Ongororo dzeboka diki dzakaratidza kuti Wainua inogona kunge iine mukana wekurapa chete, asi zvakawanikwa izvi hazvina kukwana kupfuura kutadza kwekuyedzwa kusvika pamugumo wayo mukuru. Saka, chidzidzo ichi chingangoyeukwa zvishoma nekuda kwekuvhura nzira itsva yekurapa pane kusimbisa iriko parizvino, zvichisiya mishonga yakasimba ichitsigirwa nehumbowo hwakasimba hwekiriniki.

Mishonga yeGLP-1 iri kuoma kufuratira mukudzivirira chirwere chemwoyo

Kana Wainua akasimbisa kukosha kwemishonga yeATTR-CM yakatangwa, maGLP-1 receptor agonists anoratidza kuti kudzivirira mwoyo yemwoyo kunogona kunge kuri kuenda kupi.

Kare zvainyanya kuonekwa semishonga yechirwere cheshuga nekufutisa, mishonga yeGLP-1 yava kugadzira chirwere chemwoyo chinovimbika. tsvakurudzo Zvakaratidzwa paAmerican Diabetes Association Scientific Sessions uye zvakaburitswa muJournal of the American Heart Association zvakawana kuti vanhu vakuru vane kufuta kwakanyanya uye chirwere che autoimmune vanotora GLP-1 receptor agonist vaiva nenjodzi yakaderera ye17% ye venous thromboembolism, njodzi yakaderera ye31% ye pulmonary embolism, mukana wakaderera we21% wekushanya kuchipatara chekukurumidzira uye njodzi yakaderera yekufa ne44% zvichienzaniswa nevaya vasina kurapwa. Ongororo iyi yakawanawo kudzikira kudiki kwe13% munjodzi yestroke, kunyangwe kudzikira kwakaonekwa kwe14% munjodzi yekurohwa nemoyo kwakanga kusina kukosha.

Humbowo huchiri kuda kutsanangurwa nokungwarira sezvo data pacharo riri rekucherechedza uye hariratidze kuti ndiro rakakonzera. Kunyangwe zvakadaro, rinoenderana nepfungwa dzakawanda. pattern zvichiratidza kuti mishonga yeGLP-1 inogona kuderedza njodzi yemwoyo kuburikidza nezvinopfuura kuderedza huremu chete, kusanganisira kuvandudzwa kwekudzora kweglucose mumuviri uye kudzikira kwekuzvimba mumuviri.

Kwava kuda kufamba kwakajeka. MaGLP-1 receptor agonists ari kubva pakurapa nekuchinja kwemuviri kuenda kubasa guru mukuderedza njodzi dzemwoyo kune varwere vakasarudzwa vane njodzi huru.

CHAMPION-AF inzira inobatsira yekuongorora kufarira kubvisa bhora nekukurumidza

SHANDI-AF yakaongorora mudziyo wekuvhara weWATCHMAN FLX left atrial appendage pamishonga inorwisa ropa risingashandise vitamin K (NOACs) senzira yekutanga yekuderedza njodzi yekurohwa nestroke muvarwere vane non-valvular atrial fibrillation. Shoko rayo riri nyore asi rakakosha. Nzira dzinokwezva dzekurapa dzichiri kuda kuratidza kuti dzinovandudza mhedzisiro yakaoma.

Kuedzwa kwakaenzanisa mudziyo weWATCHMAN FLX nemushonga wekuderedza ropa muvarwere vane atrial fibrillation. Kunyange hazvo varwere vakagamuchira mudziyo uyu vakasangana nematambudziko mashoma ekubuda ropa mumakore matatu, vakasanganawo nematambudziko emwoyo zvakanyanya, nezviitiko makumi masere nerimwe zvichienzaniswa nezviitiko makumi matanhatu nezvishanu muboka remishonga. Zvakawanikwa zvinoratidza kuti mudziyo uyu hausati wakwana zvakakwana kutsiva kurapwa kwekutanga kuripo iye zvino.

Mupfungwa iyoyo, CHAMPION-AF haisi dambudziko guru asi chiratidzo chemuganhu. Inobatsira kutsanangura kuti kubvisa bhora kunotsigirwa kupi nhasi uye kuti humbowo hwakasimba huchiri kudiwa kupi usati wachinja maitiro.

Nyaya yakasimba yemwoyo ichiri iyo yakaratidzwa neuchapupu

Zvidzidzo izvi zvinoratidza kuti chikamu ichi chiri kusarudza zvakanyanya, uye chingangove chivimbo, pamusoro pezvinoonekwa sekufambira mberi chaiko. Mishonga yeGLP-1 iri kumanikidza vezvemoyo kuti vafunge zvakadzama nezvekudzivirira kupfuura nzira dzekare dzekutarisira njodzi, nepo CHAMPION-AF ichiratidza kuti kunyangwe kupindira kunoda kuwana nzvimbo yakwo kuburikidza nedata remhedzisiro.

Kune ATTR-CM, mhedzisiro yeWainua inonyanya kujekesa. Pane kuvhura chitsauko chitsva chekurapa kwakabatana, yakasimbisa Attruby senzira inodiwa mukurapa kweATTR-CM uye yakasimbisa basa guru revanosimbisa hutano semusana wekutarisira. Mune nzira yakazara yekurapa kwemwoyo, izvo zvinokosha nekuti marapirwo anogona kuchinja maitiro haasi matsva, asi ndiwo anoramba achiratidza kuti anofanirwa kuvimbwa navanachiremba.

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