Mushonga chaiwo ndiyo nzira inoenda kunyika ine utano?

By EAPM Executive Director Denis Horgan; Gordon McVie, European Institute of Oncology; Angelo Paradsio, National Cancer Center 'Giovanni Paolo II', Bari, Italy; Angela Brand, Institute yePublic Health Genomics (IPHG), Maastricht University; Mark Lawler, Queens University Belfast

Mukupindura tsamba ichangopfuura muna The Lancet, Mushonga chaiwo ndiyo nzira inoenda kunyika ine utano?, vane chekuita neBrussels-based European Alliance for Personalized Medicine (EAPM) vanonzwa vachisungirwa kutaura nyaya yavo.

Vanyori vetsamba yekutanga vanopokana kuti: "Kunyangwe mushonga chaiwo uchizoshandiswa mukushandisa niche, kana ukashandiswa zvakanyanya, zvinogona kukanganisa kupindira nehurongwa hwehuwandu hwehuwandu hwevanhu husingadhuri uye hunoshanda," achiwedzera "tinotenda mushonga chaiwo. haisiriyo nzira inoenda kunyika ine hutano uye panzvimbo pezvo kukurudzira kutariswa patsva uye kuwedzera kutarisisa hutano hweveruzhinji nekudzivirira. "

Mushonga wakasarudzika ndewe "hutano hweveruzhinji nekudzivirira", nekusimbisa kwakawedzerwa pakugonesa murwere. Iyo yekupedzisira inosanganisira kuongororwa kwemararamiro - semushonga wemunhu haungovimbi pane genetics chete, asiwo neruzivo nezve, sezvakataurwa nevanyori, "kuita kwemuviri uye maitiro ekudya".

Hazvireve hazvo kunyorwa kwemajini emamiriyoni evanhu - nemari yese yevarindiri - uye hazvireve kushandura kusimbisa kubva mukushandiswa kwemishonga uye marapirwo anoshanda kune ruzhinji. Inotsvaka, panzvimbo pezvo, kuumba zvibereko zviri nani kune vashoma (vachikura nguva dzose) avo vasingashandiswi negumbeze, uye avo mari yakawanda iri kuraswa nekuda kwekuomerera kune imwe-saizi-inokodzera-zvose. methodology.

Kushandisa mari yakawanda pakurapa kusina kufanira uye kusashanda kuvanhu vazhinji vari mumapoka madiki, nekuda kwekusanzwisisa mamiriro avo - izvo zvinogona kufambiswa neongororo itsva dzemurabhoritari iyo iri kudhura nguva dzese - inopesana nekugadzira uye ichaita. chaizvoizvo zvinoreva kuti mari icharasika nokuda kwezvimwe zvinokosha zvoutano.

Mune ramangwana, kusimbiswa kwemishonga yemunhu kunogona kubva kune varwere vane zviratidzo zvekiriniki, uye kune vagari vane hutano. Izvi ndezvekuti kudzivirira sezvo mushonga unogona kuwana uye uchatungamirira kukuchengetedza kwenguva refu, hupenyu huri nani (nguva shoma inoshandiswa muzvipatara zvinodhura uye makiriniki) pamwe chete nekuramba kuchienderera mberi kurapwa kwemusha, kushandisa zvinopfeka, 'smart' mapiritsi emabhokisi nezvimwe.

Kubva pakuona kwekupa simba, varwere vanhasi vane ruzivo rwakakwana uye vane tarisiro huru maererano nekurapwa pazvirwere zvavo. Kana zvasvika pakusarudza nzira chaiyo yekurapa, tandem nevarwere, ruzivo rwekuti vekupedzisira havagone kupindura kune imwe-saizi-inokodzera-yese kurapwa, uye / kana inogona kutambura yakakosha mhedzisiro, yakakosha.

Zvakare, kana sarudzo dzakanangwa dzichizivikanwa kuti dziripo, murwere anozokwanisa kuita sarudzo achifunga nezvezvakawanda zvemararamiro - kusanganisira izvo zvambotaurwa kuita zvemuviri uye maitiro ekudya.

Pamusoro peizvi, kushandiswa kweruzivo rwemajini uye inonzi Big Data inokwanisa kuratidzira zviratidzo zvekutanga zvechirwere uye, mune zvimwe zviitiko, kufungidzira, toti, imwe kenza.

Panyaya yegomarara rakagarwa nhaka iro, iro vanyori vanoti, vari vashoma, vanobvuma kuti ruzivo rwemajini runogona kupa dzimwe mhinduro dzekuti varwere vanozopindura sei kune kumwe kurapwa. Ichi ichokwadi asi, zvakakosha, ruzivo urwu runogonawo kupa ruzivo kune chero chechipiri mhedzisiro (iyo inogona kugonesa vanachiremba kuti vasarudze kupa kurapa kwekudzivirira - uye yakawanda mari yekuchengetedza).

Ehe, kune "zvakaoma zvetsika, zvemutemo, zvemari, uye zvemagariro," maererano neruzivo rwemajini (nerumwe ruzivo rwezvekurapa) uye izvi zviri kukurukurwa padanho reEuropean Union, asi chokwadi ndechekuti rudzi urwu rwebiomarker-based. nzira ichave nemhedzisiro yakakura pakutsvagisa kwezvirwere zvakawanda kana hwaro hwakasimba hwemutemo uye hwetsika hukaiswa mukutamba.

Asi hurongwa uhu hunofanirwa kudzikamisa kuchengetedzwa kweruzivo rwevarwere pamusoro pekudiwa kwemvumo yekushandisa data kuitira kubatsira nzanga yese.

Zvichakadaro, kugadzirwa kwemushonga chaiwo kunobvumirawo kududzirwa kwezviitiko zvakawanda zvepathogenetic zvisingatsananguriki neimwe nzira, nokudaro zvichitibvumira kushandura nzira dzezvinetso zvekare.

Uye kunyangwe mutengo wemaitiro ejenomic akadaro uchinetsa panguva ino, kuyedza kunofanirwa kuitwa kuvandudza nzira dzechizvino-zvino nenzira ine hukama kune chokwadi uye nekukurumidzira zvinodiwa zvepasirese - senge kuchembera kweEurope ye500 miriyoni vangangove varwere. mhiri 28, zvakasiyana chaizvo, Member Sates.

Kupfupisa: Mushonga wega wega kukurumidza kuvandudza nzira inotungamirwa nesainzi kune hutano kune zvingango batsira zvakanyanya kuvarwere, varapi uye masisitimu ehutano zvakafanana. Izvi zvinosanganisira marapirwo arinani kune rumwe rutivi, uye kuchengetwa kwenguva refu kwemutengo kune rimwe.

Zvakanakira zvinosanganisira kugona kuita sarudzo dzine ruzivo rwezvekurapa; mukana wepamusoro wezvinoda kubuda nekuda kwekurapa-kwakanangana nekurapa; mukana wakaderedzwa wekuita kwakashata kumishonga; kutarisa pakudzivirira uye kufanotaura kwechirwere pane kuita kwachiri; kupindira kwechirwere kwekare kupfuura zvazvaibvira kare; uye kuvandudzwa kwemutengo wezvehutano.

CKudyidzana uye kuputsika kwemadziro esilo kunofanira, chokwadika, kuitika pakati pemayunivhesiti, indasitiri, vatapi vehutano nevamwe vatambi asi, nepo paine nzira refu yekuenda, chokwadi chinoramba chiripo chekuti, hongu, mushonga chaiwo "inzira inoenda kune nyika ine utano”.

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